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Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease : A Consensus Document from the Academic Research Consortium

Capodanno, Davide (author)
Univ Catania, Azienda Osped Univ Policlin G Rodolico San Marco, Catania, Italy.
Mehran, Roxana (author)
Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA.;Pharmaceut & Med Devices Agcy, Tokyo, Japan.
Krucoff, Mitchell W. (author)
Duke Univ, Med Ctr, Durham, NC USA.
show more...
Baber, Usman (author)
Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
Bhatt, Deepak L. (author)
Icahn Sch Med Mt Sinai, Mt Sinai Heart, New York, NY USA.
Capranzano, Piera (author)
Univ Catania, Azienda Osped Univ Policlin G Rodolico San Marco, Catania, Italy.
Collet, Jean-Philippe (author)
Sorbonne Univ, Hop Pitie Salpetriere, AP HP, ACTION Study Grp,Inst Cardiol, Paris, France.
Cuisset, Thomas (author)
Univ Hosp La Timone, Dept Cardiol, Intervent Cardiol Unit, Marseille, France.;Univ Hosp La Timone, Dept Cardiol, Cathlab, Marseille, France.
De Luca, Giuseppe (author)
Univ Messina, Div Cardiol, Azienda Osped Univ Policlin G Martino, Messina, Italy.;IRCCS Hosp Galeazzi St Ambrogio, Div Cardiol, Milan, Italy.
De Luca, Leonardo (author)
Azienda Osped San Camillo Forlanini, Dept Cardiothorac & Vasc Med & Surg, Div Cardiol, Rome, Italy.;UniCamillus St Camillus Int Univ Hlth Sci, Rome, Italy.
Farb, Andrew (author)
US FDA, Silver Spring, MD USA.
Franchi, Francesco (author)
Univ Florida, Div Cardiol, Coll Med, Jacksonville, FL USA.
Gibson, C. Michael (author)
Baim Inst Clin Res, Boston, MA USA.
Hahn, Joo-Yong (author)
Sungkyunkwan Univ, Heart Vasc Stroke Inst, Samsung Med Ctr, Sch Med, Seoul, South Korea.
Hong, Myeong-Ki (author)
Yonsei Univ, Severance Hosp, Div Cardiol, Coll Med, Seoul, South Korea.
James, Stefan, 1964- (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
Kastrati, Adnan (author)
Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;Deutsch Zentrum Herz Kreislauf Forsch DZHK, Munich, Germany.;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany.
Kimura, Takeshi (author)
Hirakata Kohsai Hosp, Dept Cardiol, Osaka, Japan.
Lemos, Pedro A. (author)
Hosp Israelita Albert Einstein, Sao Paulo, Brazil.
Lopes, Renato D. (author)
Duke Univ, Med Ctr, Durham, NC USA.
Magee, Adrian (author)
US FDA, Silver Spring, MD USA.
Matsumura, Ryosuke (author)
Mochizuki, Shuichi (author)
Pharmaceut & Med Devices Agcy, Tokyo, Japan.
O'Donoghue, Michelle L. (author)
Brigham & Womens Hosp, Cardiovasc Div, TIMI Study Grp, Boston, MA USA.
Pereira, Naveen L. (author)
Mayo Clin, Dept Cardiovasc Med, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA.
Rao, Sunil V. (author)
NYU Langone Hlth Syst, New York, NY USA.
Rollini, Fabiana (author)
Univ Florida, Div Cardiol, Coll Med, Jacksonville, FL USA.
Shirai, Yuko (author)
Pharmaceut & Med Devices Agcy, Tokyo, Japan.
Sibbing, Dirk (author)
Deutsch Zentrum Herz Kreislauf Forsch DZHK, Munich, Germany.;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany.;Ludwig Maximilians Univ Munchen, Munich, Germany.;Privatklin Lauterbacher Muhle Ostsee, Seeshaupt, Germany.
Smits, Peter C. (author)
Maasstad Hosp, Dept Cardiol, Rotterdam, Netherlands.
Steg, P. Gabriel (author)
Univ Paris Cite, AP HP, Paris, France.;INSERM U1148 LVTS, Paris, France.;Inst Univ France, Paris, France.
Storey, Robert F. (author)
Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, England.
ten Berg, Jurrien (author)
Maastricht Univ Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Sch Cardiovasc Dis, Maastricht, Netherlands.;St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.;Univ Med Ctr Maastricht, Dept Cardiol, Maastricht, Netherlands.
Valgimigli, Marco (author)
Univ Svizzera Italiana USI, Cardioctr Inst, Osped Cantonale, Lugano, Switzerland.;Univ Bern, Bern, Switzerland.
Vranckx, Pascal (author)
Jessa Ziekenhuis, Dept Cardiol & Crit Care Med, Hasselt, Belgium.;Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium.
Watanabe, Hirotoshi (author)
Hirakata Kohsai Hosp, Dept Cardiol, Osaka, Japan.
Windecker, Stephan (author)
Bern Univ Hosp, Dept Cardiol, Inselspital, Bern, Switzerland.
Serruys, Patrick W. (author)
Univ Galway, Dept Cardiol, Galway, Ireland.
Yeh, Robert W. (author)
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA.
Morice, Marie-Claude (author)
ICPS, Paris, France.;CERC, Paris, France.
Angiolillo, Dominick J. (author)
Univ Florida, Div Cardiol, Coll Med, Jacksonville, FL USA.
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Univ Catania, Azienda Osped Univ Policlin G Rodolico San Marco, Catania, Italy Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA.;Pharmaceut & Med Devices Agcy, Tokyo, Japan. (creator_code:org_t)
Ovid Technologies (Wolters Kluwer Health), 2023
2023
English.
In: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 0009-7322 .- 1524-4539. ; 147:25, s. 1933-1944
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Antiplatelet therapy is the mainstay of pharmacologic treatment to prevent thrombotic or ischemic events in patients with coronary artery disease treated with percutaneous coronary intervention and those treated medically for an acute coronary syndrome. The use of antiplatelet therapy comes at the expense of an increased risk of bleeding complications. Defining the optimal intensity of platelet inhibition according to the clinical presentation of atherosclerotic cardiovascular disease and individual patient factors is a clinical challenge. Modulation of antiplatelet therapy is a medical action that is frequently performed to balance the risk of thrombotic or ischemic events and the risk of bleeding. This aim may be achieved by reducing (ie, de-escalation) or increasing (ie, escalation) the intensity of platelet inhibition by changing the type, dose, or number of antiplatelet drugs. Because de-escalation or escalation can be achieved in different ways, with a number of emerging approaches, confusion arises with terminologies that are often used interchangeably. To address this issue, this Academic Research Consortium collaboration provides an overview and definitions of different strategies of antiplatelet therapy modulation for patients with coronary artery disease, including but not limited to those undergoing percutaneous coronary intervention, and consensus statements on standardized definitions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

acute coronary syndrome
coronary artery disease
percutaneous coronary intervention
therapeutics

Publication and Content Type

ref (subject category)
art (subject category)

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